The Health Benefits of Soybeans and Bowman-Birk Inhibitor Concentrate
نویسندگان
چکیده
منابع مشابه
Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate.
The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor with anticarcinogenic activities. BBI, in the form of BBI concentrate (BBIC), is currently being evaluated in clinical trials as a human cancer-preventive agent. In the present study, an enzyme-linked immunosorbent assay was used to measure BBI concentrations in serum samples collected from human subjects and animals...
متن کاملMethionine and Sulfate Increase a Bowman-Birk-Type Protease Inhibitor and Its Messenger RNA in Soybeans
A soybean cotyledon cDNA library was screened for clones representing RNAs that were more abundant in cotyledons grown on methionine-supplemented medium than in those grown on unsupplemented (basal) medium. Three isolated clones encoded the Bowman-Birk protease inhibitor (BBPI). RNA gel blot hybridization confirmed that the BBPI mRNA level is increased by methionine (Met). Met and/or sulfate su...
متن کاملSingle-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia.
The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor and a potential cancer chemopreventive agent for humans. In this Phase I clinical trial, BBI concentrate was administered as a single oral dose to 24 subjects with oral leukoplakia. Pharmacokinetics of BBI was analyzed, and subjects were monitored clinically for toxic effects. Subjects received between 25 and 800 chy...
متن کاملBowman birk inhibitor concentrate and oral leukoplakia: a randomized phase IIb trial.
Oral premalignancy serves as an ideal model for study of chemopreventive agents. Although 13-cis-retinoic acid showed reversal of oral premalignancy, toxicity, and reversal of clinical response after cessation of therapy obviated its widespread use. A search for nontoxic agents with cancer preventive activity led us to evaluate Bowman Birk Inhibitor (BBI) formulated as BBI Concentrate (BBIC). W...
متن کاملPhase I randomized double-blind placebo-controlled single-dose safety studies of Bowman-Birk inhibitor concentrate
In previously performed animal studies and Phase I-II human trials, Bowman-Birk inhibitor concentrate (BBIC) appeared to be a promising cancer chemopreventive agent. The present study describes the results of two phase I randomized double-blind placebo-controlled trials performed in male subjects to assess the safety and toxicity of the original and new formulations of BBIC administered in a si...
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ژورنال
عنوان ژورنال: Medicinal & Aromatic Plants
سال: 2012
ISSN: 2167-0412
DOI: 10.4172/2167-0412.1000e138